Description

Hydroxy-Peg1-Methylamine CAS NO 85475-01-0 is a versatile bifunctional PEG derivative, serving as a crucial linker and spacer molecule in advanced chemical synthesis. Its primary value lies in its ability to introduce hydrophilic polyethylene glycol (PEG) chains and reactive amine groups, enhancing solubility and enabling conjugation. This compound is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and material science sectors who require precise molecular modification.

Application

• Pharmaceutical Linker: A key intermediate in the synthesis of antibody-drug conjugates (ADCs) and peptide-drug conjugates, facilitating stable linkages between bioactive payloads and targeting molecules.
• PEGylation Reagent: Used to modify proteins, peptides, and small molecule therapeutics to improve pharmacokinetic properties, such as increased circulation half-life and reduced immunogenicity.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent in the creation of hydrogels, smart polymers, and surface coatings that require hydrophilic and reactive properties.
• Bioconjugation & Probe Synthesis: Facilitates the attachment of fluorescent dyes, biotin, or other reporter molecules to biomolecules for diagnostic assays and imaging applications.
• Chemical Intermediate: Serves as a building block for synthesizing more complex PEG-based derivatives, such as heterobifunctional crosslinkers with tailored reactivity.
• Surface Functionalization: Used to amine-functionalize nanoparticles, quantum dots, and other nanomaterials to enable further covalent coupling in nanomedicine development.

Basic Information

Product Name	Hydroxy-Peg1-Methylamine
CAS No.	85475-01-0
Molecular Formula	C4H11NO2
Molecular Weight	105.14 g/mol
Synonyms	2-(2-Aminoethoxy)ethanol; 2-(2-Aminoethoxy)ethan-1-ol; Amino-PEG1-alcohol; 2-[2-Aminoethoxy]ethanol; Ethanol, 2-(2-aminoethoxy)-; Aminoethoxyethanol; O-(2-Aminoethyl)ethylene glycol; Aminoethyl Cellosolve
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg1-Methylamine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and commercial applications. Quality is verified through comprehensive analytical testing, including HPLC, NMR, and titration methods. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.