Description

8-Benzyl-1-(4-Fluorophenyl)-3-(Hydroxymethyl)-1,3,8-Triazaspiro[4.5]Decan-4-One is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop new drug candidates with high efficacy and specificity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: A key building block in the multi-step production of complex Active Pharmaceutical Ingredients (APIs) targeting specific receptors.
• Preclinical Studies: Employed in the preparation of compounds for pharmacological evaluation and toxicology assessments.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for biochemical pathway analysis.

Basic Information

Product Name	8-Benzyl-1-(4-Fluorophenyl)-3-(Hydroxymethyl)-1,3,8-Triazaspiro[4.5]Decan-4-One
CAS No.	85098-63-1
Molecular Formula	C24H28FN3O2
Molecular Weight	409.50 g/mol
Synonyms	8-Benzyl-1-(4-fluorophenyl)-3-(hydroxymethyl)-1,3,8-triazaspiro[4.5]decan-4-one; 1,3,8-Triazaspiro[4.5]decan-4-one, 8-benzyl-1-(4-fluorophenyl)-3-(hydroxymethyl)-; 85098-63-1; UNII-8J6K6G6J8Q; 8-Benzyl-1-(4-fluorophenyl)-3-(hydroxymethyl)-1,3,8-triazaspiro[4.5]decan-4-one; Spirocyclic triazone derivative; 8-Benzyl-1-(p-fluorophenyl)-3-(hydroxymethyl)-1,3,8-triazaspiro[4.5]decan-4-one
EINECS	Contact for details

Quality Control

Our 8-Benzyl-1-(4-Fluorophenyl)-3-(Hydroxymethyl)-1,3,8-Triazaspiro[4.5]Decan-4-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are available upon request to support your regulatory and quality documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.