Description

(-)-trans-Anti-N2-Bpde-Dg is a high-purity, stereochemically defined polycyclic aromatic hydrocarbon (PAH) metabolite, specifically a diol epoxide derivative of benzo[a]pyrene. This compound is of critical importance as a reference standard and active metabolite in toxicological and carcinogenicity research. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in studies of DNA adduct formation, metabolic activation pathways, and chemical carcinogenesis.

Application

• Biomarker and Carcinogenicity Research: Used as a definitive standard for quantifying DNA adducts formed by benzo[a]pyrene exposure, essential for understanding cancer mechanisms.
• Metabolic Pathway Studies: Serves as a key intermediate in elucidating the metabolic activation of PAHs to their ultimate carcinogenic forms.
• Analytical Reference Standard: Critical for calibrating analytical instruments (HPLC, LC-MS, GC-MS) in environmental monitoring, food safety, and occupational health testing.
• Toxicological Assay Development: Employed in the development and validation of in vitro and in vivo assays to assess genotoxicity and mutagenicity.
• Pharmaceutical Safety Testing: Used in investigative toxicology to study drug-induced genotoxicity and to validate safety screening protocols.
• Academic and Government Research: Fundamental tool for public health and environmental science research focused on pollution impact and chemical safety.

Basic Information

Item	Details
Product Name	(-)-trans-Anti-N2-Bpde-Dg
CAS No.	85026-87-5
Molecular Formula	C20H14O3
Molecular Weight	302.33 g/mol
Synonyms	(-)-trans-anti-Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (N2-deoxyguanosine adduct); (-)-trans-anti-BPDE-N2-dG; anti-BPDE-dG Adduct; 7R,8S,9S,10R-7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene N2-deoxyguanosine Adduct; B[a]PDE-dG; BPDE-deoxyguanosine Conjugate
EINECS	Contact for details

Quality Control

Every batch of (-)-trans-Anti-N2-Bpde-Dg is produced and analyzed under strict quality protocols to ensure identity, purity, and stability for sensitive research applications. Our standard grade typically meets a purity specification of ≥95% (by HPLC). Comprehensive analytical data, including chromatographic purity (HPLC), structural confirmation (NMR, MS), and stereochemical integrity, are documented. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support regulatory submissions and ensure experimental reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is both light-sensitive and hygroscopic (moisture-sensitive). For long-term stability, store desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.