Description

(S)-(+)-3-Hydroxytetrahydrofuran CAS NO 84976-47-6 is a high-value chiral building block and intermediate, prized for its stereochemical purity and functional versatility. Its significance lies in enabling the synthesis of complex, optically active molecules, which are critical for developing pharmaceuticals and fine chemicals with specific biological activities. This compound is essential for R&D chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable source of enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, cardiovascular, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators where specific stereochemistry impacts efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require defined stereochemistry.
• Polymer Modification: Acts as a monomer or modifying agent for creating functionalized polymers with specific properties.
• Academic and Industrial Research: A valuable reagent for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	(S)-(+)-3-Hydroxytetrahydrofuran
CAS No.	84976-47-6
Molecular Formula	C4H8O2
Molecular Weight	88.11 g/mol
Synonyms	(S)-3-Hydroxytetrahydrofuran; (S)-(+)-Tetrahydro-3-furanol; (3S)-Oxolan-3-ol; (S)-Tetrahydro-3-furanol; (S)-3-Hydroxyoxolane; (S)-3-THF-OH; (S)-3-Tetrahydrofuryl alcohol; L-3-Hydroxytetrahydrofuran
EINECS	Contact for details

Quality Control

Our (S)-(+)-3-Hydroxytetrahydrofuran is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect product stability and performance. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation [α]D20	+30° to +35° (c=1 in CHCl3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.