Description

4-Chloro-5-Nitro-1H-Pyrazole-3-Carboxylic Acid is a high-value heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular construction. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its pyrazole core.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and dyes due to its electron-withdrawing nitro and carboxylic acid functionalities.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Chloro-5-Nitro-1H-Pyrazole-3-Carboxylic Acid
CAS No.	84547-92-2
Molecular Formula	C4H2ClN3O4
Molecular Weight	191.53 g/mol
Synonyms	4-Chloro-5-nitro-1H-pyrazole-3-carboxylic acid; 3-Carboxy-4-chloro-5-nitropyrazole; 1H-Pyrazole-3-carboxylic acid, 4-chloro-5-nitro-; 4-Chloro-5-nitropyrazole-3-carboxylic acid; 5-Nitro-4-chloro-1H-pyrazole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-5-Nitro-1H-Pyrazole-3-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified through modern analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.