Description

(S)-2-Hydrazino-3-(4-Hydroxy-3-Methoxyphenyl)-2-Methylpropionic Acid is a chiral, non-proteinogenic amino acid derivative featuring a hydrazino functional group and a methoxyphenol (guaiacol) moiety. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting neurological and cardiovascular pathways. It is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity, enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and cardiovascular drugs.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and constrained peptides due to its non-natural amino acid backbone and hydrazine group.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in asymmetric catalytic reactions to induce stereoselectivity.
• Ligand and Catalyst Development: Serves as a precursor for chelating ligands used in metal-catalyzed transformations and medicinal chemistry.
• Bioconjugation Chemistry: The hydrazino group enables specific conjugation strategies for labeling biomolecules or creating antibody-drug conjugates (ADCs).
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-2-Hydrazino-3-(4-Hydroxy-3-Methoxyphenyl)-2-Methylpropionic Acid
CAS No.	84488-77-7
Molecular Formula	C11H16N2O4
Molecular Weight	240.26 g/mol
Synonyms	(S)-2-Hydrazinyl-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropanoic acid; L-2-Hydrazino-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropionic acid; (2S)-2-Hydrazinyl-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropanoic acid; 2-Methyl-2-hydrazino-3-(4-hydroxy-3-methoxyphenyl)propionic acid; Guaiacol glycine hydrazine derivative; (S)-α-Methyl-3-(4-hydroxy-3-methoxyphenyl)alanine hydrazide acid form
EINECS	Contact for details

Quality Control

Our (S)-2-Hydrazino-3-(4-Hydroxy-3-Methoxyphenyl)-2-Methylpropionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider freezing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (S-enantiomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.