Description

5-Amino-2-Chloro-4-Fluorophenol is a versatile halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for creating complex molecules with specific electronic and steric properties. This compound is primarily sought after by the pharmaceutical and agrochemical industries for the development of active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders and infectious diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Dye and Pigment Manufacturing: Serves as a diazo component for producing azo dyes and high-performance pigments with excellent lightfastness and color properties.
• Liquid Crystal Materials: Building block for synthesizing fluorinated liquid crystal compounds used in display technologies.
• Polymer Modification: Intermediate for creating specialty polymers and epoxy resin hardeners, imparting flame retardancy and chemical resistance.
• Research & Development: Essential reagent in academic and industrial R&D for exploring new chemical entities and reaction pathways in medicinal chemistry.

Basic Information

Product Name	5-Amino-2-Chloro-4-Fluorophenol
CAS No.	84478-72-8
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	2-Chloro-4-fluoro-5-aminophenol; 4-Fluoro-5-amino-2-chlorophenol; 5-Amino-2-chloro-4-fluorophenol; 2-Chloro-4-fluoro-5-hydroxyaniline; 5-Amino-4-fluoro-2-chlorophenol; 4-Fluoro-2-chloro-5-aminophenol; Phenol, 5-amino-2-chloro-4-fluoro-; 5-Amino-4-fluoro-2-chlorophenol
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Chloro-4-Fluorophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment to guarantee compliance with your specific application requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be stored away from direct light exposure. Keep container tightly sealed when not in use to minimize moisture absorption and oxidation.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	145 - 150 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.