Description

1-(5-Isoquinolinylsulfonyl)-2-Methyl-Piperazine is a high-purity, specialized heterocyclic sulfonamide compound used as a key intermediate in advanced organic synthesis. Its value lies in its role as a versatile building block for the development of novel pharmacologically active molecules, particularly protein kinase inhibitors. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries, where it is utilized to create new chemical entities for drug discovery programs targeting various diseases.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel small-molecule therapeutics, especially protein kinase inhibitors for oncology and inflammatory disease research.
• Biochemical Research: Used as a tool compound or a starting material for developing specific enzyme inhibitors in proteomics and signal transduction pathway studies.
• Organic Synthesis Building Block: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its isoquinoline and piperazine motifs.
• Academic Research: Serves as a valuable reagent in university and institutional labs for investigating new synthetic methodologies and biological mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development projects for global pharmaceutical companies.

Basic Information

Product Name	1-(5-Isoquinolinylsulfonyl)-2-Methyl-Piperazine
CAS No.	84477-87-2
Molecular Formula	C14H17N3O2S
Molecular Weight	291.37 g/mol
Synonyms	2-Methyl-1-(5-isoquinolinylsulfonyl)piperazine; 2-Methyl-1-(isoquinolin-5-ylsulfonyl)piperazine; 1-(Isoquinoline-5-sulfonyl)-2-methylpiperazine; H-9, Dihydrochloride (related salt form); Protein Kinase Inhibitor H-9; CAS 84477-87-2
EINECS	Contact for details

Quality Control

Our 1-(5-Isoquinolinylsulfonyl)-2-Methyl-Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.