Description

N'-Nitrosonornicotine CAS NO 84237-38-7 is a nitrosamine derivative of nornicotine, a key compound in tobacco-specific nitrosamine (TSNA) research. Its precise synthesis and high purity are critical for toxicological studies and analytical method development. This compound is primarily required by analytical laboratories, research institutions, and regulatory bodies focused on tobacco product safety and carcinogen analysis.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for the accurate quantification of tobacco-specific nitrosamines (TSNAs) in tobacco, smoke, and related products.
• Toxicology Research: Essential for in vitro and in vivo studies investigating the carcinogenic mechanisms, metabolic pathways, and biological impact of nitrosamines.
• Method Development & Validation: Used to develop, calibrate, and validate sensitive analytical methods such as GC-MS, LC-MS/MS, and HPLC for nitrosamine detection.
• Regulatory Compliance Testing: Supports testing protocols to ensure tobacco products comply with international regulatory limits for harmful and potentially harmful constituents (HPHCs).
• Quality Control in Manufacturing: Serves as a benchmark in the QC laboratories of pharmaceutical and tobacco industries to monitor and control nitrosamine impurities.
• Academic Research: Fundamental for university-led studies in organic chemistry, environmental chemistry, and food safety related to nitrosamine formation and inhibition.

Basic Information

Product Name	N'-Nitrosonornicotine
CAS No.	84237-38-7
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	NNN; N-Nitrosonornicotine; 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanone (Note: This is NNK, a common related TSNA, often listed in searches); N'-Nitroso-nornicotine; Nornicotine, N'-nitroso-; 1-(3-Pyridinyl)-1-butanone, 4-(methylnitrosamino)- (misassociated); Tobacco-specific nitrosamine reference standard; TSNA analytical standard.
EINECS	Contact for details

Quality Control

Our N'-Nitrosonornicotine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques, to ensure it meets the exacting standards required for research and analysis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) under an inert atmosphere to prevent oxidation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., methanol, acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.