Description

trans-3-Aminocyclobutanecarboxylic Acid Hydrochloride is a high-purity, pharmaceutically relevant building block supplied as its stable hydrochloride salt. This compound is a conformationally constrained, non-proteinogenic amino acid derivative, offering unique spatial geometry for advanced medicinal chemistry research and drug design. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic candidates, particularly those targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel small molecule drugs and peptide mimetics.
• Protease Inhibitor Development: Used in research for designing inhibitors of enzymes like proteases and kinases due to its rigid cyclobutane scaffold.
• Peptidomimetics & Constrained Peptides: Incorporation into peptide chains to induce specific backbone conformations, enhancing metabolic stability and receptor selectivity.
• Ligand Synthesis for Drug Discovery: Serves as a versatile building block in fragment-based drug discovery and combinatorial chemistry libraries.
• Chemical Biology Probes: Used to create tool compounds for studying biological pathways and protein function.
• Agrochemical Research: Potential intermediate in the development of new active ingredients with unique biological activity profiles.

Basic Information

Product Name	trans-3-Aminocyclobutanecarboxylic Acid Hydrochloride
CAS No.	84182-60-5
Molecular Formula	C5H10ClNO2
Molecular Weight	151.59 g/mol
Synonyms	(1r,3r)-3-Aminocyclobutanecarboxylic Acid Hydrochloride; (1R,3R)-3-Aminocyclobutanecarboxylic Acid HCl; trans-3-ACBC HCl; (R,R)-3-Aminocyclobutanecarboxylic Acid Hydrochloride; 3-Aminocyclobutanecarboxylic Acid Hydrochloride (trans); Cyclobutane-1-carboxylic acid, 3-amino-, hydrochloride, (1R,3R)-; (+)-(1R,3R)-3-Aminocyclobutanecarboxylic Acid Hydrochloride
EINECS	Contact for details

Quality Control

Our trans-3-Aminocyclobutanecarboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.