Description

6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant synthetic utility. Its core value lies in its role as a key building block for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and psychiatric drug discovery. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for synthesis and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antipsychotic and neuroactive drug candidates.
• Biochemical Research: Used as a reference standard and a key scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Organic Synthesis: Serves as a versatile building block for constructing complex heterocyclic compounds in fine chemical production.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for pharmacological and chemical research.
• Process Development: Employed in the scale-up and optimization of synthetic routes for potential drug substances.

Basic Information

Product Name	6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride
CAS No.	84163-13-3
Molecular Formula	C12H12FN3O·HCl
Molecular Weight	269.70 g/mol (Free base: 233.24 g/mol)
Synonyms	6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole HCl; 3-(4-Piperidinyl)-6-fluoro-1,2-benzisoxazole hydrochloride; 6-Fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride; 84163-13-3; 6-Fluoro-3-(4-piperidyl)-1,2-benzisoxazole hydrochloride; 6-Fluoro-3-(piperidin-4-yl)-1,2-benzisoxazole HCl salt
EINECS	Contact for details

Quality Control

Our 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.