Description

n-α-Benzyl-D-Phenylalanine Methyl Ester Hydrochloride is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound is a critical intermediate in the research and development of novel pharmaceuticals, particularly in the creation of peptide-based therapeutics and enzyme inhibitors. It is primarily utilized by process development chemists and researchers in the pharmaceutical, biotechnology, and fine chemical industries who require high-quality, enantiomerically pure intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide drugs, protease inhibitors, and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected D-phenylalanine derivative.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric transformations to construct complex stereocenters.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Bioconjugation: Potential use in the synthesis of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.

Basic Information

Product Name	n-α-Benzyl-D-Phenylalanine Methyl Ester Hydrochloride
CAS No.	84028-90-0
Molecular Formula	C17H19NO2 • HCl
Molecular Weight	305.80 g/mol (Free base: 269.34 g/mol)
Synonyms	D-Phenylalanine, N-(phenylmethyl)-, methyl ester, hydrochloride; Methyl N-benzyl-D-phenylalaninate hydrochloride; (R)-Methyl 2-(benzylamino)-3-phenylpropanoate hydrochloride; N-Benzyl-D-phenylalanine methyl ester HCl; Bn-D-Phe-OMe • HCl; N-α-Benzyl-D-Phe-OMe hydrochloride; Benzyl-D-phenylalanine methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our n-α-Benzyl-D-Phenylalanine Methyl Ester Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is subjected to comprehensive analytical testing including chiral HPLC, NMR, and mass spectrometry to confirm identity, purity, and optical rotation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.