Description

(S)-Phenyl[[(2,2,2-Trichloroethoxy)Carbonyl]Amino]Acetic Acid is a high-value chiral building block and protected amino acid derivative essential for advanced organic synthesis. Its primary value lies in its role as a key intermediate for the preparation of enantiomerically pure peptides and pharmaceutical compounds, ensuring high stereochemical fidelity. This compound is critically needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing new active pharmaceutical ingredients (APIs) and complex molecular entities.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the asymmetric synthesis of peptide-based drugs and other bioactive molecules.
• Peptide Chemistry: Serves as a protected amino acid derivative (N-Troc-protected phenylglycine) for solid-phase and solution-phase peptide synthesis (SPPS).
• API Development: Used in research and development for constructing complex molecular architectures in new drug candidates.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in studies of enantioselective transformations.
• Fine Chemical Synthesis: A building block for synthesizing specialty chemicals requiring high enantiopurity.
• Bioconjugation: Potential use in creating labeled peptides or protein conjugates for diagnostic applications.

Basic Information

Product Name	(S)-Phenyl[[(2,2,2-Trichloroethoxy)Carbonyl]Amino]Acetic Acid
CAS No.	83846-88-2
Molecular Formula	C11H10Cl3NO4
Molecular Weight	326.56 g/mol
Synonyms	(S)-2-[[(2,2,2-Trichloroethoxy)carbonyl]amino]-2-phenylacetic acid; (S)-N-[(2,2,2-Trichloroethoxy)carbonyl]phenylglycine; (S)-Troc-Phenylglycine; (S)-N-Troc-Phenylglycine; (S)-2-Phenyl-2-[(2,2,2-trichloroethoxycarbonyl)amino]acetic acid; L-N-Troc-Phenylglycine; Troc-L-Phg-OH
EINECS	Contact for details

Quality Control

Our (S)-Phenyl[[(2,2,2-Trichloroethoxy)Carbonyl]Amino]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards typical for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.