Description

(2E)-4-(3,4-Difluorophenyl)-4-Oxobut-2-Enoic Acid is a high-purity, synthetic organic compound featuring a difluorophenyl-substituted α,β-unsaturated ketone carboxylic acid structure. This molecular architecture makes it a versatile and critical pharmaceutical intermediate for the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds. It is essential for research institutions and manufacturers engaged in the development of new chemical entities, where precise molecular control and reliable supply are paramount.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of novel fluorinated drug candidates, including kinase inhibitors and other targeted therapies.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes in academic and industrial labs.
• Agrochemical Intermediate: Potential application in the synthesis of advanced, fluorinated pesticides and herbicides, leveraging the biological activity imparted by the fluorine atoms.
• Material Science Precursor: Can be utilized in the synthesis of specialized monomers or ligands for advanced polymers and metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) producing bespoke compounds for client projects.

Basic Information

Product Name	(2E)-4-(3,4-Difluorophenyl)-4-Oxobut-2-Enoic Acid
CAS No.	83844-24-0
Molecular Formula	C10H6F2O3
Molecular Weight	212.15 g/mol
Synonyms	(E)-4-(3,4-Difluorophenyl)-4-oxobut-2-enoic acid; 4-(3,4-Difluorobenzoyl)acrylic acid; (E)-4-(3,4-Difluorobenzoyl)acrylic acid; trans-4-(3,4-Difluorobenzoyl)acrylic acid; 2-Butenoic acid, 4-(3,4-difluorophenyl)-4-oxo-, (2E)-; 83844-24-0; 3,4-Difluorophenyl 4-oxo-2-butenoyl ketone derivative
EINECS	Contact for details

Quality Control

Our (2E)-4-(3,4-Difluorophenyl)-4-Oxobut-2-Enoic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.