Description

6-Fluorobenzo(A)Pyrene-7,8-Dihydrodiol is a fluorinated derivative of a benzo[a]pyrene metabolite, a compound of significant interest in biochemical and toxicological research. This specific fluorinated analog is crucial for studying metabolic activation pathways, DNA adduct formation, and the mechanisms of polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. It serves as a valuable reference standard and research chemical for analytical laboratories, environmental health scientists, and pharmaceutical researchers investigating xenobiotic metabolism and biomarker development.

Application

• Biochemical Research: Used as a critical intermediate or reference standard in studies of cytochrome P450 metabolism and epoxide hydrolase activity related to PAHs.
• Toxicology Studies: Employed to investigate the carcinogenic mechanisms of fluorinated PAH derivatives and their comparative potency relative to parent compounds.
• Analytical Method Development: Serves as a high-purity calibration standard for advanced chromatographic (HPLC, GC-MS) and spectroscopic techniques to detect and quantify PAH metabolites in complex matrices.
• Environmental Monitoring: Acts as a model compound for tracing the environmental fate and human exposure biomarkers of fluorinated aromatic hydrocarbons.
• DNA Adduct Research: Utilized in *in vitro* and *in vivo* studies to form and characterize specific DNA adducts, helping elucidate mutation spectra and repair mechanisms.
• Pharmaceutical Discovery: May be used in early-stage research to explore the structure-activity relationships of PAH derivatives and their interactions with biological targets.

Basic Information

Product Name	6-Fluorobenzo(A)Pyrene-7,8-Dihydrodiol
CAS No.	83768-92-7
Molecular Formula	C₂₀H₁₃FO₂
Molecular Weight	304.32 g/mol
Synonyms	6-Fluorobenzo[a]pyrene-7,8-dihydrodiol; 6-F-B[a]P-7,8-diol; 7,8-Dihydroxy-7,8-dihydro-6-fluorobenzo[a]pyrene; 6-Fluoro-BP-7,8-diol; 6-F-BPDE precursor; 6-Fluorobenzo(a)pyrene 7,8-dihydrodiol; (+/-)-6-Fluoro-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene
EINECS	Contact for details

Quality Control

Our 6-Fluorobenzo(A)Pyrene-7,8-Dihydrodiol is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity assay and identity confirmation via techniques such as HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing all relevant specifications is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.