Description

4-Fluorobenzimidazole-2-Carboxylic Acid is a high-purity fluorinated heterocyclic building block of significant importance in advanced organic synthesis. This compound serves as a critical precursor for the development of novel pharmaceutical intermediates and agrochemicals, where the introduction of a fluorine atom can dramatically alter biological activity and metabolic stability. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in developing new-generation herbicides, fungicides, and insecticides where fluorination enhances efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of advanced polymers and organic electronic materials requiring fluorinated benzimidazole units.
• Chemical Biology Probes: Utilized to create fluorescent tags and molecular probes for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	4-Fluorobenzimidazole-2-Carboxylic Acid
CAS No.	83431-74-7
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	4-Fluoro-1H-benzimidazole-2-carboxylic acid; 2-Carboxy-4-fluorobenzimidazole; 4-Fluoro-2-benzimidazolecarboxylic acid; 4-Fluoro-1H-benzo[d]imidazole-2-carboxylic acid; 4-F-BIA; 4-Fluorobenzimidazol-2-carboxylic Acid; 83431-74-7; 4-Fluorobenzimidazolecarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Fluorobenzimidazole-2-Carboxylic Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.