Description

Methyl 1',2'-Dihydro-2'-Oxo-Spiro[Cyclopropane-1,3'-[3H]Indole]-6'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound is of significant value for its role as a key building block in the synthesis of novel bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating new therapeutic agents, especially those targeting central nervous system disorders and other complex disease pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those with spirocyclic or fused heterocyclic architectures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) with potential biological activity.
• API Synthesis: Used in the development and scale-up processes for Active Pharmaceutical Ingredients (APIs), especially in neurological and psychiatric drug discovery.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs) specializing in complex organic molecules.

Basic Information

Product Name	Methyl 1',2'-Dihydro-2'-Oxo-Spiro[Cyclopropane-1,3'-[3H]Indole]-6'-Carboxylate
CAS No.	83414-46-4
Molecular Formula	C13H11NO3
Molecular Weight	229.23 g/mol
Synonyms	Methyl 1,2-dihydro-2-oxospiro[cyclopropane-1,3'-indole]-6'-carboxylate; 6'-Methoxycarbonyl-1,2-dihydro-2-oxospiro[cyclopropane-1,3'-indole]; Spiro[cyclopropane-1,3'-[3H]indole]-6'-carboxylic acid, 1',2'-dihydro-2'-oxo-, methyl ester; Methyl 2-oxo-1,2-dihydrospiro[cyclopropane-1,3'-indole]-6'-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 1',2'-Dihydro-2'-Oxo-Spiro[Cyclopropane-1,3'-[3H]Indole]-6'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for demanding research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.