Description

2-Amino-5-(Trifluoromethoxy)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its amino and carboxylic acid functional groups, as well as a trifluoromethoxy substituent. This unique structure makes it a critical intermediate for synthesizing advanced molecules, particularly in the pharmaceutical and agrochemical sectors where the trifluoromethoxy group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is essential for research chemists and process development teams in fine chemical, pharmaceutical, and advanced material industries seeking to incorporate this privileged scaffold into new active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) drugs, anti-inflammatory agents, and other therapeutic small molecules.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for advanced electronic materials, including liquid crystals for displays and organic light-emitting diode (OLED) components.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid and amino groups allow for facile incorporation into peptide chains or for use as a linker in bioconjugation chemistry for drug delivery systems.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments, particularly those requiring high lightfastness and unique color properties.
• Research & Development (R&D): A valuable reagent for medicinal chemistry and material science research in academic and industrial laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	2-Amino-5-(Trifluoromethoxy)Benzoic Acid
CAS No.	83265-56-9
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	5-(Trifluoromethoxy)anthranilic acid; 2-Amino-5-(trifluoromethoxy)benzoic acid; Benzoic acid, 2-amino-5-(trifluoromethoxy)-; 2-Amino-5-(trifluoromethoxy)benzoic acid; Anthranilic acid, 5-(trifluoromethoxy)-; 5-(Trifluoromethoxy)-2-aminobenzoic acid
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(Trifluoromethoxy)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.