Description

3-Phenylbicyclo[1.1.1]pentan-1-amine hydrochloride is a high-purity, synthetically valuable organic building block with a unique, rigid bicyclic scaffold. This compound is essential for medicinal chemistry research and development, particularly in the design of novel bioactive molecules and pharmaceutical intermediates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to explore three-dimensional chemical space and modulate the physicochemical properties of lead compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Medicinal Chemistry: Used in fragment-based drug discovery and lead optimization to introduce steric bulk and improve metabolic stability.
• Agrochemical Research: Serves as a precursor in the development of new active ingredients with unique modes of action.
• Chemical Biology: Employed as a probe or linker molecule for studying protein-ligand interactions and biological pathways.
• Academic Research: Utilized in methodological studies and the synthesis of complex, strained organic architectures.
• Material Science: Potential precursor for specialty polymers or additives requiring rigid, aromatic-functionalized components.

Basic Information

Product Name	3-Phenylbicyclo[1.1.1]pentan-1-amine hydrochloride
CAS No.	83249-11-0
Molecular Formula	C11H14ClN
Molecular Weight	195.69 g/mol
Synonyms	1-Amino-3-phenylbicyclo[1.1.1]pentane hydrochloride; 3-Phenylbicyclo[1.1.1]pentan-1-amine HCl; 3-Phenyl-1-bicyclo[1.1.1]pentanylaminium chloride; 1-Bicyclo[1.1.1]pentanamine, 3-phenyl-, hydrochloride; [1.1.1]Propellane, 3-amino-1-phenyl-, hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Phenylbicyclo[1.1.1]pentan-1-amine hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.