Description

3-Phenylbicyclo[1.1.1]pentane-1-carboxylic acid is a high-value, synthetically challenging bicyclic carboxylic acid building block. Its unique, highly strained [1.1.1]propellane-derived structure makes it a critical intermediate for medicinal chemistry and advanced materials research. This compound is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers for developing novel bioactive molecules and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates, particularly in fragment-based drug discovery and for creating bioisosteres of phenyl and benzoic acid groups.
• Agrochemical Research: Used in the development of novel herbicides and pesticides with unique modes of action due to its rigid, three-dimensional geometry.
• Material Science: Serves as a precursor for high-performance polymers, liquid crystals, and organic electronic materials requiring rigid, aromatic-bridged structures.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags to study protein-ligand interactions and cellular processes.
• Academic & Industrial R&D: Fundamental research reagent for exploring new synthetic methodologies involving strained hydrocarbon systems and C-H functionalization.
• Peptidomimetics: Incorporation into peptide backbones to induce specific conformational constraints and enhance metabolic stability.

Basic Information

Product Name	3-Phenylbicyclo[1.1.1]pentane-1-carboxylic Acid
CAS No.	83249-04-1
Molecular Formula	C12H12O2
Molecular Weight	188.22 g/mol
Synonyms	3-Phenylbicyclo[1.1.1]pentane-1-carboxylic acid; 3-Phenyl[1.1.1]propellane-1-carboxylic acid; 1-Carboxy-3-phenylbicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-phenyl-; 3-Phenyl-BCP-COOH; 3-Ph-BCP-1-COOH
EINECS	Contact for details

Quality Control

Our 3-Phenylbicyclo[1.1.1]pentane-1-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for advanced research and development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is compatible with strong acids and organic solvents but should be kept away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by Titration)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.