Description

2-Bromo-1-(Difluoromethoxy)-4-Nitrobenzene is a specialized aromatic compound featuring bromo, difluoromethoxy, and nitro substituents, making it a valuable multifunctional building block in advanced synthesis. Its unique structure provides distinct reactivity for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific halogenated and fluorinated motifs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for introducing halogen and fluorine atoms into lead structures.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy and nitro groups contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic compounds for electronic applications, including liquid crystal displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized nitro- and halogen-containing dyes and pigments.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	2-Bromo-1-(Difluoromethoxy)-4-Nitrobenzene
CAS No.	83189-97-3
Molecular Formula	C7H4BrF2NO3
Molecular Weight	268.01 g/mol
Synonyms	1-Bromo-2-(difluoromethoxy)-5-nitrobenzene; 2-Bromo-α,α-difluoro-4-nitroanisole; 4-Nitro-2-bromo-1-(difluoromethoxy)benzene; Benzene, 2-bromo-1-(difluoromethoxy)-4-nitro-; 2-Bromo-4-nitro-1-(difluoromethoxy)benzene; 5-Nitro-2-bromophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(Difluoromethoxy)-4-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.