Description

2,8-Bis(Trifluoromethyl)-4-Chloroquinoline CAS NO 83012-13-9 is a specialized fluorinated quinoline derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring two trifluoromethyl groups and a chloro substituent, makes it a critical intermediate for developing compounds with tailored electronic and physicochemical properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology, where the fluorine atoms can enhance metabolic stability and bioavailability.
• Agrochemical Research: Used in developing next-generation pesticides, herbicides, and fungicides, leveraging the lipophilicity and stability imparted by the trifluoromethyl groups.
• Material Science: Serves as a monomer or functional unit in the creation of advanced organic electronic materials, such as OLEDs (Organic Light-Emitting Diodes) and semiconductors, due to its electron-deficient quinoline core.
• Ligand & Catalyst Development: Employed in the design of novel chelating ligands for transition metal catalysis, enabling more efficient and selective chemical transformations.
• Fluorine Chemistry Research: An important substrate for studying structure-activity relationships (SAR) and the effects of polyfluorination on molecular properties in medicinal and synthetic chemistry.

Basic Information

Product Name	2,8-Bis(Trifluoromethyl)-4-Chloroquinoline
CAS No.	83012-13-9
Molecular Formula	C11H4ClF6N
Molecular Weight	299.60 g/mol
Synonyms	4-Chloro-2,8-bis(trifluoromethyl)quinoline; 2,8-Bis(trifluoromethyl)-4-chloroquinoline; 4-Chloro-2,8-di(trifluoromethyl)quinoline; Quinoline, 4-chloro-2,8-bis(trifluoromethyl)-; 83012-13-9
EINECS	Contact for details

Quality Control

Our 2,8-Bis(Trifluoromethyl)-4-Chloroquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to guarantee batch-to-batch consistency and support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.