Description

Tolrestat is a potent and selective aldose reductase inhibitor, a key compound in pharmaceutical research and development. Its primary value lies in its ability to modulate the polyol pathway, making it a critical tool for investigating diabetic complications, particularly neuropathy and retinopathy. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and life sciences sectors developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced investigational drugs targeting metabolic disorders.
• Diabetic Complication Research: Used extensively in preclinical and biochemical research to study the inhibition of aldose reductase and its role in diabetic neuropathy, retinopathy, and nephropathy.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Biochemical Pathway Studies: A vital tool for elucidating the polyol pathway's biochemistry and its implications in various disease states beyond diabetes.
• Active Pharmaceutical Ingredient (API) Development: Employed in the R&D and scale-up processes for potential new chemical entities (NCEs).

Basic Information

Product Name	Tolrestat
CAS No.	82964-04-3
Molecular Formula	C₁₇H₁₄F₃NO₃
Molecular Weight	337.29 g/mol
Synonyms	N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine; Tolrestat; Alredase; AY-27773; LY-177801; Tolrestatum; N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthyl]carbothioyl]-N-methylglycine
EINECS	Contact for details

Quality Control

Our Tolrestat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, residual solvent analysis, and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.