Description

2,3(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-, 2-(Phenylmethyl) 3-(1,1-Dimethylethyl) Ester is a high-purity, advanced pharmaceutical intermediate crucial for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role as a key building block in medicinal chemistry, enabling the development of novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in research and development (R&D) laboratories for structure-activity relationship (SAR) studies and lead optimization.
• Organic Synthesis Reagent: Serves as a versatile precursor for constructing complex isoquinoline-based molecular frameworks in synthetic chemistry.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	2,3(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-, 2-(Phenylmethyl) 3-(1,1-Dimethylethyl) Ester
CAS No.	82716-89-0
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	2-(Benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester; 2-(Benzyloxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; 1,2,3,4-Tetrahydroisoquinoline-2,3-dicarboxylic acid 2-benzyl 3-tert-butyl ester; 2-Cbz-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester; 2-Cbz-Tic-OtBu; Z-Tic-OtBu; 2,3(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(phenylmethyl) 3-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), suitable for demanding research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality system is designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.