Description

5-o-Demethyl-4,5-Bis-o-[(1,1-Dimethylethyl)dimethylsilyl]-22,23-dihydro-avermectin A1A is a key protected intermediate in the synthesis of advanced macrocyclic lactone compounds. This compound is of critical importance for pharmaceutical research and development, particularly in the creation of novel antiparasitic and insecticidal agents. It is primarily utilized by research institutions and manufacturers in the agrochemical and pharmaceutical industries for the development of next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel macrocyclic lactone-based drugs and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development and production of advanced, high-efficacy insecticidal and acaricidal compounds.
• Veterinary Medicine Development: Serves as a precursor for creating new endectocide treatments for animal health.
• Chemical Synthesis: Employed in organic synthesis for the selective introduction of functional groups onto the avermectin core structure.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of related bioactive molecules.

Basic Information

Product Name	5-o-Demethyl-4,5-Bis-o-[(1,1-Dimethylethyl)dimethylsilyl]-22,23-Dihydro-Avermectin A1A
CAS No.	82590-57-6
Molecular Formula	C51H86O14Si2
Molecular Weight	955.5 g/mol
Synonyms	22,23-Dihydro-5-O-demethyl-4,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]avermectin A1a; 5-O-Demethyl-4,5-bis-O-(tert-butyldimethylsilyl)-22,23-dihydroavermectin A1a; 4,5-Bis-O-(tert-butyldimethylsilyl)-5-O-demethyl-22,23-dihydroavermectin A1a; 22,23-Dihydro-5-O-demethyl-4,5-bis-O-(TBDMS)avermectin A1a; Protected Dihydroavermectin A1a Intermediate; TBDMS-protected Avermectin Derivative
EINECS	Contact for details

Quality Control

Our 5-o-Demethyl-4,5-Bis-o-[(1,1-Dimethylethyl)dimethylsilyl]-22,23-dihydro-avermectin A1A is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for advanced synthetic intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.