Description

(4S)-4A,5,6,7,8,8A-Hexahydro-8Aβ-Hydroxy-4α-(Hydroxymethyl)-3,4Aα,8,8-Tetramethylnaphthalen-1(4H)-One is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. Its complex decalin core structure with multiple chiral centers makes it a valuable building block for the construction of complex natural product analogs and pharmacologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical R&D departments for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for complex target molecules.
• Organic Synthesis Building Block: Used in advanced multi-step syntheses to construct intricate polycyclic frameworks found in terpenoids and steroids.
• Asymmetric Catalysis Research: Serves as a sophisticated substrate or ligand precursor in studies exploring new catalytic methodologies.
• Natural Product Synthesis: Critical for the laboratory-scale total synthesis of natural products with decalin or hydrindane structural motifs.
• Fragrance & Flavor Chemistry: Potential intermediate for the synthesis of high-value, complex odorants and flavor compounds due to its terpene-like backbone.
• Material Science Research: Investigated as a precursor for specialty polymers or liquid crystals requiring rigid, chiral molecular components.

Basic Information

Product Name	(4S)-4A,5,6,7,8,8A-Hexahydro-8Aβ-Hydroxy-4α-(Hydroxymethyl)-3,4Aα,8,8-Tetramethylnaphthalen-1(4H)-One
CAS No.	82526-30-5
Molecular Formula	C15H24O3
Molecular Weight	252.35 g/mol
Synonyms	(4S)-4a,5,6,7,8,8a-Hexahydro-8a-hydroxy-4-(hydroxymethyl)-3,4a,8,8-tetramethylnaphthalen-1(4H)-one; (4S,4aS,8aR)-4-(Hydroxymethyl)-4a,5,6,7,8,8a-hexahydro-8a-hydroxy-3,4a,8,8-tetramethylnaphthalen-1(4H)-one; 8aβ-Hydroxy-4α-(hydroxymethyl)-3,4aα,8,8-tetramethyl-4,4a,5,6,7,8,8a,9-octahydronaphthalen-1-one; (4S,4aS,8aR)-4-(Hydroxymethyl)-4a,8a-dihydroxy-3,4a,8,8-tetramethyl-4,4a,5,6,7,8,8a,9-octahydronaphthalen-1-one; Decalin-1-one derivative
EINECS	Contact for details

Quality Control

Our (4S)-4A,5,6,7,8,8A-Hexahydro-8Aβ-Hydroxy-4α-(Hydroxymethyl)-3,4Aα,8,8-Tetramethylnaphthalen-1(4H)-One is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, chiral analysis to confirm stereochemical purity, and standard identification tests. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.