Description

(8R)-6,8-Dihydro-8-Methyl-5H-Benzo[G]-1,3-Benzodioxolo[6,5,4-De]Quinoline-8,10-Diol is a complex, optically active alkaloid derivative with a fused polycyclic structure. This compound matters as a high-value pharmaceutical intermediate and a key scaffold in medicinal chemistry research, offering a unique structural motif for drug discovery. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug candidates, particularly those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Investigated for its potential biological activity and interactions with various enzymes or receptors.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of advanced pharmaceutical ingredients.

Basic Information

Product Name	(8R)-6,8-Dihydro-8-Methyl-5H-Benzo[G]-1,3-Benzodioxolo[6,5,4-De]Quinoline-8,10-Diol
CAS No.	82404-36-2
Molecular Formula	C₁₉H₁₇NO₄
Molecular Weight	323.34 g/mol
Synonyms	(8R)-8-Methyl-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]quinoline-8,10-diol; (R)-8-Methyl-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]quinoline-8,10-diol; 8R-Dihydro-8-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline-8,10-diol; (8R)-6,8-Dihydro-8-methyl-5H-benzo[g][1,3]benzodioxolo[6,5,4-de]quinoline-8,10-diol; Berberastine (8R-isomer); (8R)-Berberastine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development use, with typical purity levels meeting or exceeding 95% (HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Specifications can be aligned with customer-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Optical Rotation	Contact for details
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.