Description

6-Bromo-1,4-dioxaspiro[4.4]nonane is a versatile brominated spirocyclic ketal building block, essential for advanced organic synthesis. Its unique structure provides a protected, functionalized core for constructing complex molecules with high stereochemical control. This intermediate is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, including spirocyclic and bridged ring systems.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides requiring specific, rigid molecular architectures.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic materials with tailored properties.
• Asymmetric Synthesis: Employed in chiral pool synthesis and the construction of enantiomerically pure compounds due to its prochiral nature.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings.
• Natural Product Analogues: Used in the synthetic studies of natural products containing spiroketal or tetrahydrofuran motifs.

Basic Information

Product Name	6-Bromo-1,4-dioxaspiro[4.4]nonane
CAS No.	82235-82-3
Molecular Formula	C8H13BrO2
Molecular Weight	221.09 g/mol
Synonyms	6-Bromo-1,4-dioxaspiro[4.4]nonane; 6-Bromospiro[1,3-dioxolane-2,1'-cyclopentane]; 1,4-Dioxaspiro[4.4]nonane, 6-bromo-; 6-Bromo-1,4-dioxaspiro[4.4]nonan; Bromo-dioxaspiro nonane; Spirocyclic bromo ketal
EINECS	Contact for details

Quality Control

Our 6-Bromo-1,4-dioxaspiro[4.4]nonane is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.