Description

4-(Bromodifluoromethoxy)Nitrobenzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a nitro group and a bromodifluoromethoxy moiety, enabling precise chemical modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where the difluoromethoxy group can improve biological activity and environmental profile.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, contributing to the tuning of dielectric properties and molecular alignment.
• Cross-Coupling Reactions: The bromine atom acts as a handle for versatile palladium-catalyzed reactions (e.g., Suzuki, Heck), allowing for the construction of complex biaryl structures.
• Functional Dye & Pigment Development: Incorporated into the synthesis of specialized dyes and pigments where nitro and fluorine substituents alter color properties and lightfastness.
• Polymer Modification: Used to introduce fluorinated aromatic units into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties of high-performance plastics.

Basic Information

Product Name	4-(Bromodifluoromethoxy)Nitrobenzene
CAS No.	81932-04-9
Molecular Formula	C7H4BrF2NO3
Molecular Weight	268.01 g/mol
Synonyms	1-Bromo-4-(bromodifluoromethoxy)benzene (nitro derivative context); 4-Nitro-α,α-difluorobromoanisole; p-(Bromodifluoromethoxy)nitrobenzene; Nitrobenzene, 4-(bromodifluoromethoxy)-; Benzene, 1-(bromodifluoromethoxy)-4-nitro-; Bromodifluoromethoxy Nitrobenzene; 4-Nitrophenyl bromodifluoromethyl ether
EINECS	Contact for details

Quality Control

Our 4-(Bromodifluoromethoxy)Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.