Description

2-Chloro-5,6,7,8-Tetrahydroquinazoline is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its core quinazoline scaffold, partially saturated and functionalized with a reactive chlorine atom, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Chemical Synthesis Building Block: The reactive chloro group enables further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions, facilitating library synthesis for high-throughput screening.
• Material Science Research: Investigated as a monomer or functional additive in the creation of specialized polymers and organic electronic materials.
• Academic & Contract Research: Essential for methodological studies in organic chemistry and for contract research organizations (CROs) serving the life sciences sector.

Basic Information

Product Name	2-Chloro-5,6,7,8-Tetrahydroquinazoline
CAS No.	81532-76-5
Molecular Formula	C8H9ClN2
Molecular Weight	168.62 g/mol
Synonyms	2-Chloro-5,6,7,8-tetrahydroquinazoline; 5,6,7,8-Tetrahydro-2-chloroquinazoline; 2-Chlorotetrahydroquinazoline; Quinazoline, 2-chloro-5,6,7,8-tetrahydro-; 81532-76-5
EINECS	Contact for details

Quality Control

Our 2-Chloro-5,6,7,8-Tetrahydroquinazoline is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.