Description

n-(4-Amino-6,7-Dimethoxyquinazol-2-Yl)-n-Methyl-Propylenediamine, Hydrochloride is a high-purity, pharmacologically active quinazoline derivative supplied as a hydrochloride salt. This compound is a critical advanced pharmaceutical intermediate for the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of small-molecule drug candidates, particularly kinase inhibitors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthesis routes for final active compounds.
• Oncology Research: Potential intermediate for compounds targeting specific cancer pathways due to the quinazoline core structure.
• Biochemical Assay Development: Utilized as a standard or reference compound in high-throughput screening and biochemical testing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	n-(4-Amino-6,7-Dimethoxyquinazol-2-Yl)-n-Methyl-Propylenediamine, Hydrochloride
CAS No.	81403-69-2
Molecular Formula	C₁₄H₂₂ClN₅O₂
Molecular Weight	327.81 g/mol
Synonyms	N-[4-Amino-6,7-dimethoxy-2-quinazolinyl]-N-methyl-1,3-propanediamine hydrochloride; 1,3-Propanediamine, N-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-methyl-, hydrochloride; N-Methyl-N-(4-amino-6,7-dimethoxyquinazolin-2-yl)propane-1,3-diamine hydrochloride; 81403-69-2; Quinazoline derivative intermediate; PD 153035 HCl (related analogue); EGFR inhibitor intermediate
EINECS	Contact for details

Quality Control

Our n-(4-Amino-6,7-Dimethoxyquinazol-2-Yl)-n-Methyl-Propylenediamine, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.