Description

2-Chloro-6-Nitroquinoline-4-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular scaffold, featuring chloro, nitro, and cyano substituents, makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and specialized intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting infectious diseases or cancer, due to the quinoline core's biological relevance.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the nitro and cyano groups can be modified to enhance activity.
• Material Science: Serves as a building block for creating organic semiconductors, dyes, and photoactive materials for electronic applications.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce the quinoline moiety into more complex structures.
• Academic & Contract Research: Essential for methodological studies and library synthesis in university and CRO (Contract Research Organization) settings for discovering new chemical entities.

Basic Information

Product Name	2-Chloro-6-Nitroquinoline-4-Carbonitrile
CAS No.	81257-01-4
Molecular Formula	C10H4ClN3O2
Molecular Weight	233.61 g/mol
Synonyms	6-Nitro-2-chloroquinoline-4-carbonitrile; 2-Chloro-6-nitro-4-quinolinecarbonitrile; 4-Quinolinecarbonitrile, 2-chloro-6-nitro-; 2-Chloro-6-nitroquinoline-4-carbonitrile; Quinoline-4-carbonitrile, 2-chloro-6-nitro-; 2-Chloro-6-nitro-4-cyanoquinoline
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Nitroquinoline-4-Carbonitrile is manufactured under a strict quality management system. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry to verify identity, purity, and conformity. Our rigorous quality testing ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.