Description

3,5-Methano-2H-Cyclopenta[B]Thiophen-6-Amine,Hexahydro-(9Ci) is a specialized bicyclic amine derivative featuring a fused thiophene and cyclopentane ring system, which serves as a valuable and versatile synthetic intermediate. This compound's unique constrained molecular architecture makes it a critical building block for constructing complex pharmacophores and advanced materials. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry, catalyst development, and the synthesis of novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its rigid structure can impart specific biological activity.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and novel polymers due to its fused ring system containing sulfur and nitrogen heteroatoms.
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	3,5-Methano-2H-Cyclopenta[B]Thiophen-6-Amine,Hexahydro-(9Ci)
CAS No.	81237-80-1
Molecular Formula	C8H13NS
Molecular Weight	155.26 g/mol
Synonyms	Hexahydro-3,5-methano-2H-cyclopenta[b]thiophen-6-amine; 3,5-Methano-2H-cyclopenta[b]thiophen-6-amine, hexahydro-; 6-Aminohexahydro-3,5-methano-2H-cyclopenta[b]thiophene; Bicyclo[3.3.0]octane-2-thiophene-6-amine derivative; (1R,3S,5R,6S)-6-Amino-3-thiatricyclo[3.3.0.0³,⁷]octane (stereoisomer specific); Contact for additional IUPAC and trade names.
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and every batch is analyzed using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (if applicable), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.