Description

Boc-(4-Aminophenyl)Acetic Acid is a protected amino acid derivative, a crucial building block in modern organic synthesis and pharmaceutical research. Its primary value lies in its role as a key intermediate for constructing complex peptide-based molecules and active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a protected phenylglycine derivative into peptide chains.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for the amine functionality, allowing for selective deprotection in multi-step syntheses.
• API Development: Serves as a precursor in the research and scale-up production of novel Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Utilized in the preparation of labeled compounds, antibody-drug conjugates (ADCs), and other bioconjugates due to its reactive carboxylic acid and protected amine groups.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	Boc-(4-Aminophenyl)Acetic Acid
CAS No.	81196-09-0
Molecular Formula	C₁₃H₁₇NO₄
Molecular Weight	251.28 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-4-aminophenylacetic Acid; 2-[(4-{[(tert-Butoxy)carbonyl]amino}phenyl)acetic Acid; Boc-4-Aminophenylacetic Acid; Boc-Phe(4-NH2)-OH; (4-{[(tert-Butoxy)carbonyl]amino}phenyl)acetic Acid; N-Boc-4-aminophenylacetic Acid; tert-Butyl (4-carboxymethylphenyl)carbamate
EINECS	Contact for details

Quality Control

Our Boc-(4-Aminophenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.