Description

3-Chloro-1-(4-Fluorophenyl)Propan-1-One is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Organic Synthesis & Chemical Research: Employed in academic and industrial R&D for cross-coupling reactions, carbonyl chemistry, and the introduction of fluorinated aromatic systems.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, dyes, and functional materials requiring specific halogenated aromatic motifs.

Basic Information

Product Name	3-Chloro-1-(4-Fluorophenyl)Propan-1-One
CAS No.	81112-09-6
Molecular Formula	C9H8ClFO
Molecular Weight	186.61 g/mol
Synonyms	3-Chloro-1-(4-fluorophenyl)-1-propanone; 4-Fluorophenacyl Chloride; 1-(4-Fluorophenyl)-3-chloropropan-1-one; 4'-Fluorophenacyl Chloride; γ-Chloro-4'-fluoropropiophenone; 3-Chloro-1-(p-fluorophenyl)propan-1-one; 3-Chloro-1-(4-fluorophenyl)propanone; 81112-09-6
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-1-(4-Fluorophenyl)Propan-1-One is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.