Description

Thiocellobiose is a sulfur-containing derivative of the disaccharide cellobiose, where a thiol or thioglycosidic bond replaces a typical oxygen glycosidic linkage. This structural modification is critical for its role as a potent and specific inhibitor of various β-glucosidase enzymes, making it a valuable biochemical tool. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and enzymology sectors. The compound, identified by CAS No. 80951-92-4, enables precise studies of carbohydrate metabolism and enzyme mechanism inhibition.

Application

• Enzyme Inhibition Studies: Serves as a specific active-site directed inhibitor for β-glucosidases and related glycosyl hydrolases in mechanistic biochemical research.
• Pharmaceutical Research: Used as a biochemical probe in drug discovery programs targeting metabolic disorders like Gaucher's disease, where glucocerebrosidase activity is implicated.
• Glycobiology & Carbohydrate Chemistry: Acts as a key intermediate or reference standard in the synthesis and study of thio-oligosaccharides and glycomimetics.
• Diagnostic Reagent Development: Employed in the design and calibration of enzymatic assays for clinical diagnostics and high-throughput screening.
• Agricultural Biochemistry: Investigated for its potential effects on cellulase enzymes in pests or soil microbes, supporting the development of novel biocontrol agents.
• Biocatalyst Research: Used to study and engineer enzyme specificity in industrial biocatalysis for biomass conversion and biofuel production.

Basic Information

Product Name	Thiocellobiose
CAS No.	80951-92-4
Molecular Formula	C12H22O10S
Molecular Weight	358.36 g/mol
Synonyms	4-Thiocellobiose; Cellobiose, 4-thio-; 4-S-Cellobiose; 4-Thio-β-D-glucopyranosyl-(1→4)-D-glucopyranose; β-D-Glucopyranosyl-4-thio-β-D-glucopyranoside; Thiocellobiose (mixed anomers); 4-Thio-cellobiose; 4'-Thiocellobiose
EINECS	Contact for details

Quality Control

Our Thiocellobiose is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the product should be kept under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture absorption. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.