Description

2(1H)-Quinolinone, 3,4-Dihydro-6-(3-(4-(3-Methylphenyl)-1-Piperazinyl)-1-Propenyl)- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and biotechnology industries engaged in creating new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates, especially in neurological and psychiatric research.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry: Serves as a defined starting material or intermediate in scaling up API manufacturing processes under GMP conditions.
• Biochemical Research: Potential use as a tool compound or ligand in pharmacological assays to study specific receptor interactions.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes.

Basic Information

Product Name	2(1H)-Quinolinone, 3,4-Dihydro-6-(3-(4-(3-Methylphenyl)-1-Piperazinyl)-1-Propenyl)-
CAS No.	80834-57-7
Molecular Formula	C23H27N3O
Molecular Weight	361.48 g/mol
Synonyms	6-[(E)-3-[4-(3-Methylphenyl)piperazin-1-yl]prop-1-en-1-yl]-3,4-dihydro-1H-quinolin-2-one; 6-[3-[4-(3-Methylphenyl)-1-piperazinyl]-1-propenyl]-3,4-dihydro-2(1H)-quinolinone; (E)-6-(3-(4-(3-Methylphenyl)piperazin-1-yl)prop-1-en-1-yl)-3,4-dihydroquinolin-2(1H)-one; Aripiprazole Intermediate Derivative; Quinolinone piperazine derivative; OPC-14597 related compound
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical development. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and impurity profiles. Quality is assured through analytical methods including HPLC, GC, and NMR. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements for pre-clinical and clinical stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.