Description

4-Iodobicyclo[2.2.2]octane-1-carboxylic acid is a highly functionalized, rigid bicyclic organic compound featuring both a carboxylic acid and an iodine substituent. This unique structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry and materials science research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those requiring a rigid, three-dimensional scaffold.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and for introducing iodine atoms for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Agrochemical Research: Employed in the development of new active ingredients with specific steric and electronic properties.
• Ligand and Catalyst Synthesis: The carboxylic acid group allows for derivatization into chelating ligands for metal complexes used in catalysis.
• Materials Science Precursor: Potential use in creating functionalized monomers for polymers with unique thermal or mechanical properties.
• Academic Research: A valuable tool for studying reaction mechanisms and developing new synthetic methodologies involving strained bicyclic systems.

Basic Information

Product Name	4-Iodobicyclo[2.2.2]octane-1-carboxylic Acid
CAS No.	80745-61-5
Molecular Formula	C9H13IO2
Molecular Weight	280.10 g/mol
Synonyms	1-Carboxy-4-iodobicyclo[2.2.2]octane; 4-Iodobicyclo[2.2.2]octane-1-carboxylic acid; Bicyclo[2.2.2]octane-1-carboxylic acid, 4-iodo-; 4-Iodo-1-bicyclo[2.2.2]octanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Iodobicyclo[2.2.2]octane-1-carboxylic acid is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.