Description

n-Trityl-L-Glutamic Acid Bis(Diethyl Ammonium) Salt is a high-purity, protected amino acid derivative salt, essential for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical building block, offering enhanced solubility and stability for the controlled introduction of glutamic acid into complex molecular architectures. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic peptides and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled incorporation of L-glutamic acid with its side-chain protected, enabling the synthesis of complex peptide sequences.
• Pharmaceutical Intermediate: In the research and development of peptide-based drugs, prodrugs, and targeted therapeutic agents.
• Bioconjugation & Labeling: For the site-specific modification of peptides, proteins, or other biomolecules where a protected glutamic acid residue is required.
• Chemical Biology Research: As a tool compound for studying enzyme-substrate interactions, receptor binding, and metabolic pathways involving glutamic acid.
• Fine Chemical Synthesis: As a chiral synthon for the asymmetric synthesis of non-proteinogenic amino acids and other specialized organic molecules.

Basic Information

Product Name	n-Trityl-L-Glutamic Acid Bis(Diethyl Ammonium) Salt
CAS No.	80514-74-5
Molecular Formula	C37H53N3O4
Molecular Weight	603.84 g/mol
Synonyms	L-Glutamic acid, N-(triphenylmethyl)-, bis(diethylammonium) salt; N-Trityl-L-glutamic acid diethylammonium salt; Fmoc-Glu(OtBu)-OH diethylammonium salt analog (protected form); Triphenylmethyl-L-glutamic acid bis(diethylamine) salt; N-α-Tritylglutamic acid diethylamine salt; Protected L-glutamate salt; Peptide synthesis building block 80514-74-5.
EINECS	Contact for details

Quality Control

Our n-Trityl-L-Glutamic Acid Bis(Diethyl Ammonium) Salt is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality management system supports compliance with relevant standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% L-isomer
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.