Description

Thiodigalactoside is a synthetic, non-hydrolyzable disaccharide analog specifically designed as a potent and selective inhibitor of galectin-3. This compound matters because it is a critical research tool for studying carbohydrate-protein interactions, particularly the role of galectin-3 in inflammation, fibrosis, and cancer progression. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life science sectors who require high-purity biochemicals for assay development, target validation, and mechanistic studies.

Application

• Galectin-3 Research: Primary tool for specifically inhibiting galectin-3 in in vitro and in vivo studies to elucidate its biological functions.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and validate novel therapeutic candidates targeting galectin-3 pathways.
• Biochemical Assays: Serves as a reference standard and competitive inhibitor in binding studies, including ELISA, SPR (Surface Plasmon Resonance), and ITC (Isothermal Titration Calorimetry).
• Cancer Research: Investigated for its potential to block galectin-3-mediated tumor growth, metastasis, and angiogenesis in preclinical models.
• Fibrosis Studies: Applied in research on cardiac, renal, and hepatic fibrosis where galectin-3 is a key mediator.
• Inflammation & Immunology: Used to study the role of galectin-3 in macrophage activation, cytokine production, and chronic inflammatory diseases.

Basic Information

Product Name	Thiodigalactoside
CAS No.	80441-61-8
Molecular Formula	C12H22O10S
Molecular Weight	358.37 g/mol
Synonyms	TDG; 1,1'-Thiodi-β-D-galactopyranose; β-D-Galactopyranosyl 1-thio-β-D-galactopyranoside; Galectin-3 Inhibitor; Lactose thioacetal; Thiodigalactopyranoside; 3,3'-Dithiodigalactose (related); S-Lactosylcysteine (precursor)
EINECS	Contact for details

Quality Control

Our Thiodigalactoside is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details
Biological Activity	Galectin-3 Inhibition (IC50)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.