Description

Hexahydro-1-(2,4,8,10-Tetrakis-tert-butyldibenzo[D,F][1,3,2]dioxaphosphepin-6-yl)-1H-azepine is a sophisticated organophosphorus ligand with a sterically hindered, electron-rich structure. This compound matters as a highly effective catalyst component, enabling precise control over reaction pathways in advanced chemical synthesis. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries for developing novel catalytic processes, particularly in asymmetric synthesis and cross-coupling reactions.

Application

• Catalyst Ligand in Asymmetric Synthesis: Used as a chiral ligand for transition metal catalysts (e.g., Pd, Rh, Ru) in enantioselective hydrogenation, hydroformylation, and C-C bond-forming reactions.
• Pharmaceutical Intermediate Manufacturing: Facilitates the synthesis of complex, chiral active pharmaceutical ingredients (APIs) where high stereoselectivity is critical.
• Agrochemical Research & Development: Employed in the catalytic synthesis of novel, biologically active compounds for crop protection.
• Polymerization Catalyst Component: Acts as a ligand in metal-catalyzed polymerization reactions to produce polymers with specific tacticity or functional groups.
• Fine Chemical and Specialty Chemical Production: Enables efficient and selective catalytic steps in multistep syntheses of high-value chemicals.
• Academic and Industrial R&D: Serves as a valuable tool for methodological development in organic and organometallic chemistry.

Basic Information

Product Name	Hexahydro-1-(2,4,8,10-Tetrakis-tert-butyldibenzo[D,F][1,3,2]dioxaphosphepin-6-yl)-1H-azepine
CAS No.	80399-60-6
Molecular Formula	C41H58NO2P
Molecular Weight	627.88 g/mol
Synonyms	1-(Hexahydroazepin-1-yl)-2,4,8,10-tetra-tert-butyl-6H,12H-dibenzo[d,f][1,3,2]dioxaphosphepin 6-oxide; TADDOL-derived Phosphite-Azepine Ligand; Azepine-substituted TADDOL Phosphite; Sterically Hindered Phosphite Ligand; Chiral Dioxaphosphepin Ligand; 6-(1-Azepanyl)-2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin
EINECS	Contact for details

Quality Control

Our production of Hexahydro-1-(2,4,8,10-Tetrakis-tert-butyldibenzo[D,F][1,3,2]dioxaphosphepin-6-yl)-1H-azepine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including NMR (1H, 13C, 31P), HPLC for purity, and chiral analysis to ensure structural integrity and high enantiomeric excess where applicable. Certificates of Analysis (COA) with full spectral data are provided to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.