Description

5-Bromo-6-Fluoro-2-Methylquinoline is a high-purity, halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and functional materials, where its specific bromo-fluoro substitution pattern enables precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to develop new active ingredients for crop protection products, leveraging its halogenated quinoline scaffold.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for OLEDs or charge-transport molecules.
• Chemical Biology: Employed as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies.
• Catalyst & Ligand Synthesis: Utilized to create complex nitrogen-containing ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP conditions where required.

Basic Information

Product Name	5-Bromo-6-Fluoro-2-Methylquinoline
CAS No.	80290-18-2
Molecular Formula	C₁₀H₇BrFN
Molecular Weight	240.07 g/mol
Synonyms	2-Methyl-5-bromo-6-fluoroquinoline; 6-Fluoro-5-bromo-2-methylquinoline; Quinoline, 5-bromo-6-fluoro-2-methyl-; 5-Bromo-6-fluoro-2-methylquinoline; 80290-18-2 (CAS); 5-Br-6-F-2-Me-quinoline
EINECS	Contact for details

Quality Control

Our 5-Bromo-6-Fluoro-2-Methylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We can support development projects requiring compliance with ICH guidelines and can tailor specifications for cGMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.