Description

3-(4-Fluorophenyl)-6-(Trifluoromethyl)Indan-1-One is a high-value fluorinated indanone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture, featuring both phenyl and trifluoromethyl substituents, makes it an essential building block for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its rigid, fluorinated structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	3-(4-Fluorophenyl)-6-(Trifluoromethyl)Indan-1-One
CAS No.	80272-38-4
Molecular Formula	C16H10F4O
Molecular Weight	294.25 g/mol
Synonyms	1-Indanone, 3-(4-fluorophenyl)-6-(trifluoromethyl)-; 6-(Trifluoromethyl)-3-(4-fluorophenyl)-1-indanone; 3-(p-Fluorophenyl)-6-(trifluoromethyl)indan-1-one; 80272-38-4; FC-001; FPI (Fluorophenyl Indanone) Intermediate; 3-(4-Fluorophenyl)-6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Fluorophenyl)-6-(Trifluoromethyl)Indan-1-One is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.