Description

4-Nitro-4'-(Trifluoromethyl)-1,1'-Biphenyl is a high-value biphenyl derivative distinguished by its nitro and trifluoromethyl substituents. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, prized for its ability to impart unique electronic and steric properties to target molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a core structural unit in the development of advanced electronic display materials and organic light-emitting diodes (OLEDs) due to its rigid biphenyl backbone and electron-withdrawing groups.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and as a scaffold for constructing complex polycyclic aromatic systems in academic and industrial research.
• Polymer & Resin Modifier: Incorporated into specialty polymers to modify thermal stability, refractive index, and chemical resistance for high-performance coatings and engineering plastics.

Basic Information

Item	Detail
Product Name	4-Nitro-4'-(Trifluoromethyl)-1,1'-Biphenyl
CAS No.	80245-34-7
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	4-Nitro-4'-(trifluoromethyl)biphenyl; 1-Nitro-4-[4-(trifluoromethyl)phenyl]benzene; 4'-(Trifluoromethyl)-4-nitro-1,1'-biphenyl; p-Nitro-p'-(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-4-carbonitrile, 4'-nitro-; (4-Nitrophenyl)(4-(trifluoromethyl)phenyl)
EINECS	Contact for details

Quality Control

Our production of 4-Nitro-4'-(Trifluoromethyl)-1,1'-Biphenyl adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques including HPLC, GC, and NMR to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality system is designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and consistency for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light). For long-term storage, consider under an inert atmosphere to maintain purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.