Description

1,2-Dihydro-1,2-Dihydroxydibenzo(A)Pyrene is a key dihydrodiol metabolite of the polycyclic aromatic hydrocarbon (PAH) Benzo[a]pyrene. This compound is of significant interest in toxicological and environmental research as a critical intermediate in the metabolic activation pathway leading to DNA adduct formation. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in studies of carcinogenesis, metabolic pathways, and environmental pollutant analysis.

Application

• Toxicology Research: Used as a standard or reference material in studies investigating the metabolic activation and carcinogenic mechanisms of Benzo[a]pyrene.
• Environmental Analysis: Serves as an analytical standard for the detection and quantification of PAH metabolites in environmental and biological samples.
• Biomarker Studies: Employed in the development and validation of assays to measure DNA adducts and other biomarkers of PAH exposure.
• Drug Metabolism Research: Acts as a probe substrate in studies focusing on cytochrome P450 and epoxide hydrolase enzyme activities.
• Chemical Synthesis: Used as a building block or intermediate in the synthesis of more complex molecules for research purposes.
• Quality Control & Assurance: Functions as a certified reference material (CRM) for calibrating analytical instrumentation in regulatory and compliance testing.

Basic Information

Product Name	1,2-Dihydro-1,2-Dihydroxydibenzo(A)Pyrene
CAS No.	80155-85-7
Molecular Formula	C₂₀H₁₄O₂
Molecular Weight	286.33 g/mol
Synonyms	1,2-Dihydro-1,2-dihydroxybenzo[a]pyrene; (+/-)-trans-1,2-Dihydroxy-1,2-dihydrobenzo[a]pyrene; Benzo[a]pyrene 1,2-dihydrodiol; 1,2-Dihydroxy-1,2-dihydrobenzo[a]pyrene; B[a]P-1,2-diol; 1,2-Dihydrodiol-3,4-epoxide precursor; BP 1,2-dihydrodiol
EINECS	Contact for details

Quality Control

Our 1,2-Dihydro-1,2-Dihydroxydibenzo(A)Pyrene is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and analytical applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Solubility	Soluble in DMSO, Acetone; Slightly soluble in Methanol
Residue on Ignition	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.