Description

6,7,8-Trifluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester is a high-value fluorinated quinoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for the development of novel active pharmaceutical ingredients (APIs), particularly in the synthesis of complex molecules with enhanced biological activity and metabolic stability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for its unique structural and electronic properties imparted by the trifluoro substitution pattern.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antibacterial and antiviral agents, leveraging the bioisosteric properties of fluorine.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, where the fluorinated quinoline core contributes to improved efficacy and environmental profile.
• Material Science Precursor: Acts as a monomer or ligand in the creation of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorescent tag or probe due to the quinoline scaffold.
• Organic Synthesis Reagent: Serves as a versatile substrate for further functionalization, including hydrolysis, amidation, and cross-coupling reactions.

Basic Information

Product Name	6,7,8-Trifluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	80104-36-5
Molecular Formula	C₁₂H₈F₃NO₃
Molecular Weight	271.19 g/mol
Synonyms	Ethyl 6,7,8-Trifluoro-4-hydroxyquinoline-3-carboxylate; 4-Hydroxy-6,7,8-trifluoro-3-quinolinecarboxylic Acid Ethyl Ester; 6,7,8-Trifluoro-4-hydroxy-3-quinolinecarboxylic Acid Ethyl Ester; 3-Quinolinecarboxylic acid, 6,7,8-trifluoro-4-hydroxy-, ethyl ester; Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
EINECS	Contact for details

Quality Control

Our 6,7,8-Trifluoro-4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.