Description

5,6-Difluoro-2-Methyl-Quinoline is a high-purity, fluorinated quinoline derivative serving as a critical building block in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the fluorine atoms, which are essential for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by material scientists exploring functional organic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoroquinoline core enhances stability and bioavailability.
• Material Science Research: Serves as a precursor for organic light-emitting diodes (OLEDs) and other electronic materials due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the design of fluorescent tags and molecular probes for studying biological processes.
• Catalyst Ligand Scaffold: The nitrogen and fluorine atoms make it a potential candidate for developing novel ligands in transition metal catalysis.
• Academic & Contract Research: Utilized in universities and CROs for methodological development and exploratory synthesis projects.

Basic Information

Product Name	5,6-Difluoro-2-Methyl-Quinoline
CAS No.	80076-50-2
Molecular Formula	C₁₀H₇F₂N
Molecular Weight	179.17 g/mol
Synonyms	2-Methyl-5,6-difluoroquinoline; 5,6-Difluoro-2-methylquinoline; Quinoline, 5,6-difluoro-2-methyl-; 80076-50-2; 2-Methyl-5,6-difluorochinolin; 5,6-Difluoro-2-methyl-1-azanaphthalene
EINECS	Contact for details

Quality Control

Our 5,6-Difluoro-2-Methyl-Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.