Description

5,6-Difluoro-1,2,3,4-Tetrahydro-2-Methylquinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a partially saturated quinoline scaffold with strategically placed fluorine atoms, enabling precise modulation of electronic properties, lipophilicity, and metabolic stability in target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel drug candidates, particularly in central nervous system (CNS) and oncology research, where the fluorine atoms and tetrahydroquinoline core are leveraged to fine-tune bioactivity and pharmacokinetic profiles.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where its structure contributes to enhanced efficacy and environmental persistence.
• Material Science Research: Serves as a precursor for advanced organic electronic materials, such as charge-transport layers or fluorophores, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed as a backbone for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Utilized in the design of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	5,6-Difluoro-1,2,3,4-Tetrahydro-2-Methylquinoline
CAS No.	80076-46-6
Molecular Formula	C₁₀H₁₁F₂N
Molecular Weight	183.20 g/mol
Synonyms	2-Methyl-5,6-difluoro-1,2,3,4-tetrahydroquinoline; 5,6-Difluoro-2-methyl-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-5,6-difluoro-2-methylquinoline; 2-Methyl-5,6-difluorotetrahydroquinoline; 80076-46-6; Quinoline, 5,6-difluoro-1,2,3,4-tetrahydro-2-methyl-
EINECS	Contact for details

Quality Control

Our 5,6-Difluoro-1,2,3,4-Tetrahydro-2-Methylquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. For custom synthesis or specific purity grades (e.g., >98%, >99%), please contact our technical sales team to discuss your requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.