Description

Smz/Tmp CAS NO 8064-90-2 is a synergistic antibacterial combination of sulfamethoxazole and trimethoprim, commonly known as co-trimoxazole. This combination is critical for its enhanced bactericidal effect, overcoming resistance mechanisms more effectively than either component alone. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for producing a wide range of antibacterial formulations.

Application

• Pharmaceutical API: Primary use in the manufacture of oral tablets, suspensions, and injectable solutions for systemic antibacterial therapy.
• Treatment of Bacterial Infections: Formulated for conditions such as urinary tract infections (UTIs), acute otitis media, chronic bronchitis exacerbations, and traveler's diarrhea.
• Opportunistic Infection Prophylaxis: Used in the production of medications for preventing and treating Pneumocystis jirovecii pneumonia (PCP), particularly in immunocompromised patients.
• Veterinary Pharmaceuticals: Incorporated into medicated feeds and treatments for bacterial infections in livestock and companion animals.
• Research & Development: Serves as a reference standard and raw material in antimicrobial research and new drug development studies.

Basic Information

Product Name	Smz/Tmp
CAS No.	8064-90-2
Molecular Formula	C14H18N4O3 • C10H11N3O3S
Molecular Weight	533.55 g/mol (combined molar mass for the 5:1 ratio)
Synonyms	Co-trimoxazole; Sulfamethoxazole and Trimethoprim; SMZ-TMP; Bactrim (trade name); Septra (trade name); Sulfatrim; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide combined with 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine; Cotrimoxazol
EINECS	Contact for details

Quality Control

Our Smz/Tmp is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical use, with compliance to relevant pharmacopoeial monographs (e.g., USP, EP, BP). A comprehensive Certificate of Analysis (COA) detailing identity, potency, purity, and related substances is provided with every shipment to guarantee supply reliability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Sulfamethoxazole Content	95.0% - 105.0% of labeled claim
Trimethoprim Content	95.0% - 105.0% of labeled claim
Water (Karl Fischer)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.