Description

Croton Oil is a fixed oil expressed from the seeds of *Croton tiglium* L., known for its potent biological activity and historical use in traditional medicine. Its primary value lies in its content of phorbol esters, which are powerful skin irritants and tumor promoters, making it a critical compound for biomedical and pharmacological research. This product is essential for researchers in toxicology, dermatology, and cancer studies, as well as for specialized applications in chemical synthesis and reference standard preparation.

Application

• Biomedical Research: Used as a potent tumor promoter and inflammatory agent in experimental models for cancer and dermatological studies.
• Pharmacological Studies: Serves as a key source of phorbol esters for investigating protein kinase C (PKC) activation pathways and cellular signaling mechanisms.
• Toxicology Reference: Employed as a standard irritant in skin sensitization and toxicity testing protocols.
• Chemical Synthesis: Acts as a starting material or intermediate for the derivatization of phorbol esters and related diterpenes.
• Traditional Medicine Research: Studied for its historical use and pharmacological effects in ethnopharmacology.

Basic Information

Product Name	Croton Oil
CAS No.	8001-28-3
Molecular Formula	Not applicable (Fixed oil, complex mixture)
Molecular Weight	Not applicable
Synonyms	Tiglium Oil; Oleum Tiglii; Crotonis Oleum; Croton Tiglium Seed Oil; Crotonis Tiglii Seminis Oleum; Crotonis Tiglii Oleum; Croton Seed Oil; Crotonis Semen Oleum
EINECS	232-307-4

Quality Control

Our Croton Oil is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research purposes. While specific pharmacopeial monographs may not be standard for this material, quality is assured through identity confirmation, purity assessment, and stability testing. A comprehensive Certificate of Analysis (COA) detailing key parameters is provided with each batch to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Description	Pale yellow to brownish-yellow, viscous oil; characteristic odor
Identification	Complies (TLC/IR)
Refractive Index	1.470 - 1.480 (at 20°C)
Acid Value	≤ 20.0 mg KOH/g
Saponification Value	200 - 220 mg KOH/g
Iodine Value	100 - 120 (Wijs)
Relative Density	0.935 - 0.950 (at 20°C)
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.